A drug treatment that mimics fasting can also provide the same benefit, study finds.... Intestinal stem cells from mice that fasted for 24 hours, at right, produced much more substantial intestinal organoids than stem cells from mice that did not fast, at left. Credit: Maria Mihaylova and Chia-Wei Cheng A s people age, their intestinal stem cells begin to lose their ability to regenerate. These stem cells are the source for all new intestinal cells, so this decline can make it more difficult to recover from gastrointestinal infections or other conditions that affect the intestine. In fasting mice, cells begin breaking down fatty acids instead of glucose, a change that stimulates the stem cells to become more regenerative. The researchers found that they could also boost regeneration with a molecule that activates the same metabolic switch. Such an intervention could potentially help older people recovering from GI infections or cancer patients undergoing chemot...
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A s the worldwide death toll from tobacco use continues to climb—it’s currently six million per year and is expected to top eight million by 2030, according to the World Health Organization—efforts to unlock the secrets of nicotine addiction take on a distinct urgency. “Nicotine is one of the most difficult drugs to quit,” says Ines Ibanez-Tallon, a scientists in the lab of Nathaniel Heintz, who is James and Marilyn Simons Professor at the Rockefeller University. For sure, while 70 percent of cigarette smokers in the U.S. say they would like to quit, each year only 3 percent are able to do so successfully. Now, in her latest paper, Ibanez-Tallon and colleagues from Rockefeller, Mount Sinai Medical School, and the National Institute of Biological Sciences, China, move us one step closer to understanding how nicotine maintains its powerful grip on the brain. The research, published this week in the Proceedings of the National Academy of Science , identifies specific chemica...
F or patients with mild cognitive impairment, don’t be surprised if your health care provider prescribes exercise rather than medication. A new guideline for medical practitioners says they should recommend twice-weekly exercise to people with mild cognitive impairment to improve memory and thinking. The recommendation is part of an updated guideline for mild cognitive impairment published in the Dec. 27 online issue of Neurology , the medical journal of the American Academy of Neurology. “Regular physical exercise has long been shown to have heart health benefits, and now we can say exercise also may help improve memory for people with mild cognitive impairment,” says Ronald Petersen, M.D., Ph.D., lead author, director of the Alzheimer’s Disease Research Center, Mayo Clinic, and the Mayo Clinic Study of Aging. “What’s good for your heart can be good for your brain.” Dr. Petersen is the Cora Kanow Professor of Alzheimer’s Disease Research. Mild cognitive impairment is a...
Disturbing human experiments aren’t something the average person thinks too much about. Rather, the progress achieved in the last 150 years of human history is an accomplishment we’re reminded of almost daily. Achievements made in fields like biomedicine and psychology mean that we no longer need to worry about things like deadly diseases or masturbation as a form of insanity. For better or worse, we have developed more effective ways to gather information, treat skin abnormalities, and even kill each other. But what we are not constantly reminded of are the human lives that have been damaged or lost in the name of this progress. The following is a list of the 30 most disturbing human experiments in history. 30. The Tearoom Sex Study Sociologist Laud Humphreys often wondered about the men who commit impersonal sexual acts with one another in public restrooms. He wondered why “tearoom sex” — fellatio in public restrooms — led to the majority of homosexual arrests in ...
From a simulated bioattack on London's Underground to scientists self-testing hydrogen cyanide, a book about science under wraps exposes numerous horrors...... THE 26 July 1963 is widely remembered for the devastating earthquake that killed thousands of people in the city of Skopje, then in Yugoslavia. Far fewer know it as the date of a secret military trial on the London Underground, which aimed to simulate another sort of catastrophic event: the release of anthrax in an enclosed public space. At around midday, a small box of powder was dropped from the window of a Northern Line train, just as it pulled out of the south London station of Colliers Wood. As the box smashed and released its contents, hundreds of men, women and children were exposed to spores of Bacillus globigii, unaware that they had just become test subjects in one of the largest ever field trials of a simulated biological attack. As Secret Science explains, B. globigii is considered a human pathogen wit...
We regularly find ourselves in situations in which we talk to others. We talk to friends in a different way than we do to strangers. One important skill for this is not just understanding what the other person is saying but also recognizing who is talking. Therefore, the voice of our conversation partner helps us. Until now, scientists could not agree on exactly which regions in the brain allow us to recognize voices. "Very valid statements about which brain areas are responsible for which functions are derived from investigations in patients with lesions. If a certain part of the brain is injured and therefore a certain function fails, both components can be related to each other", says Claudia Roswandowitz, scientist at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) in Leipzig, and first author of a study which has revealed key findings about voice recognition. Roswandowitz, along with other researchers from the Research Group Neural Mechanism...